Diagnostic testing for hypertension, diabetes, and hypercholesterolaemia in low-income and middle-income countries: a cross-sectional study of data for 994 185 individuals from 57 nationally representative surveys


Journal article


Ochmann S, von Polenz I, Marcus ME, Theilmann M, Flood D, Agoudavi K, Aryal KK, Bahendeka S, Bicaba B, Bovet P, Campos Caldeira Brant L, Carvalho Malta D, Damasceno A, Farzadfar F, Gathecha G, Ghanbari A, Gurung M, Guwatudde D, Houehanou C, Houinato D, Hwalla N, Jorgensen JA, Karki KB, Lunet N, Martins J, Mayige M, Moghaddam SS, Mwalim O, Mwangi KJ, Norov B, Quesnel-Crooks S, Rezaei N, Sibai AM, Sturua L, Tsabedze L, Wong-McClure R, Davies J, Geldsetzer P, Bärnighausen T, Atun R, Manne-Goehler J, Vollmer S
The Lancet Global Health, vol. 11(9), 2023, pp. E1363-E1371

DOI: 10.1016/S2214-109X(23)00280-2

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APA   Click to copy
S, O., von Polenz I, ME, M., M, T., D, F., K, A., … S, V. (2023). Diagnostic testing for hypertension, diabetes, and hypercholesterolaemia in low-income and middle-income countries: a cross-sectional study of data for 994 185 individuals from 57 nationally representative surveys. The Lancet Global Health, 11(9), E1363–E1371. https://doi.org/10.1016/S2214-109X(23)00280-2


Chicago/Turabian   Click to copy
S, Ochmann, von Polenz I, Marcus ME, Theilmann M, Flood D, Agoudavi K, Aryal KK, et al. “Diagnostic Testing for Hypertension, Diabetes, and Hypercholesterolaemia in Low-Income and Middle-Income Countries: a Cross-Sectional Study of Data for 994 185 Individuals from 57 Nationally Representative Surveys.” The Lancet Global Health 11, no. 9 (2023): E1363–E1371.


MLA   Click to copy
S, Ochmann, et al. “Diagnostic Testing for Hypertension, Diabetes, and Hypercholesterolaemia in Low-Income and Middle-Income Countries: a Cross-Sectional Study of Data for 994 185 Individuals from 57 Nationally Representative Surveys.” The Lancet Global Health, vol. 11, no. 9, 2023, pp. E1363–E1371, doi:10.1016/S2214-109X(23)00280-2 .


BibTeX   Click to copy

@article{ochmann2023a,
  title = {Diagnostic testing for hypertension, diabetes, and hypercholesterolaemia in low-income and middle-income countries: a cross-sectional study of data for 994 185 individuals from 57 nationally representative surveys},
  year = {2023},
  issue = {9},
  journal = {The Lancet Global Health},
  pages = {E1363-E1371},
  volume = {11},
  doi = {10.1016/S2214-109X(23)00280-2 },
  author = {S, Ochmann and von Polenz I and ME, Marcus and M, Theilmann and D, Flood and K, Agoudavi and KK, Aryal and S, Bahendeka and B, Bicaba and P, Bovet and L, Campos Caldeira Brant and D, Carvalho Malta and A, Damasceno and F, Farzadfar and G, Gathecha and A, Ghanbari and M, Gurung and D, Guwatudde and C, Houehanou and D, Houinato and N, Hwalla and JA, Jorgensen and KB, Karki and N, Lunet and J, Martins and M, Mayige and SS, Moghaddam and O, Mwalim and KJ, Mwangi and B, Norov and S, Quesnel-Crooks and N, Rezaei and AM, Sibai and L, Sturua and L, Tsabedze and R, Wong-McClure and J, Davies and P, Geldsetzer and T, Bärnighausen and R, Atun and J, Manne-Goehler and S, Vollmer}
}

Abstract

Background
Testing for the risk factors of cardiovascular disease, which include hypertension, diabetes, and hypercholesterolaemia, is important for timely and effective risk management. Yet few studies have quantified and analysed testing of cardiovascular risk factors in low-income and middle-income countries (LMICs) with respect to sociodemographic inequalities. We aimed to address this knowledge gap.

Methods
In this cross-sectional analysis, we pooled individual-level data for non-pregnant adults aged 18 years or older from nationally representative surveys done between Jan 1, 2010, and Dec 31, 2019 in LMICs that included a question about whether respondents had ever had their blood pressure, glucose, or cholesterol measured. We analysed diagnostic testing performance by quantifying the overall proportion of people who had ever been tested for these cardiovascular risk factors and the proportion of individuals who met the diagnostic testing criteria in the WHO package of essential noncommunicable disease interventions for primary care (PEN) guidelines (ie, a BMI >30 kg/m 2 or a BMI >25 kg/m 2 among people aged 40 years or older). We disaggregated and compared diagnostic testing performance by sex, wealth quintile, and education using two-sided t tests and multivariable logistic regression models.

Findings
Our sample included data for 994 185 people from 57 surveys. 19·1% (95% CI 18·5–19·8) of the 943 259 people in the hypertension sample met the WHO PEN criteria for diagnostic testing, of whom 78·6% (77·8–79·2) were tested. 23·8% (23·4–24·3) of the 225 707 people in the diabetes sample met the WHO PEN criteria for diagnostic testing, of whom 44·9% (43·7–46·2) were tested. Finally, 27·4% (26·3–28·6) of the 250 573 people in the hypercholesterolaemia sample met the WHO PEN criteria for diagnostic testing, of whom 39·7% (37·1–2·4) were tested. Women were more likely than men to be tested for hypertension and diabetes, and people in higher wealth quintiles compared with those in the lowest wealth quintile were more likely to be tested for all three risk factors, as were people with at least secondary education compared with those with less than primary education.

Interpretation
Our study shows opportunities for health systems in LMICs to improve the targeting of diagnostic testing for cardiovascular risk factors and adherence to diagnostic testing guidelines. Risk-factor-based testing recommendations rather than sociodemographic characteristics should determine which individuals are tested.




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